Transglutaminase Activity in Alzheimer’s Disease
نویسنده
چکیده
Cover image: immunofluorescence staining of tTG (green) and tTG activity (red) in a brain blood vessel of the APP23 Alzheimer mouse model as used in Chapter 5. APP23 mice are originally from healthcare company Novartis. Image printed with permission of Novartis. Chapter images: immunofluorescence stainings of collagen (green) in culture plates after removal of cells, as described in Chapter 4.
منابع مشابه
Transglutaminase in neurological disease
Transglutaminase catalyzes the formation of intermolecular isopeptide crosslinks in polypeptides [7]. Because the crosslink is insensitive to proteolysis, polymers extensively crosslinked by transglutaminase are extremely resistant. Thus keratinocyte transglutaminase is responsible for the formation of the insoluble envelope of the corneocyte, which protects the epidermis against chemical and p...
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